越来越多的证据提示核苷酸剪切修复通路基因的单核苷酸多态性(single nucleotide polymorphism,SNP)在膀胱癌的病因学中起着重要作用。然而,迄今为止,在此通路中只有有限数目的基因和变异得到评估。本实验中,作者设计了一个由803对肿瘤和健康对照样本组成的病例-对照研究,运用一个综合性通路基础上的方法评估了26个核酸剪切修复基因中207个标签和潜在功能性SNP在膀胱癌发病风险中的作用。结果发现,17 There is a growing body of evidence that single nucleotide polymorphisms (SNPs) in nucleotide excision repair pathway genes play an important role in the etiology of bladder cancer. However, to date, only a limited number of genes and variants in this pathway have been evaluated. In this experiment, we designed a case-control study of 803 pairs of oncology and healthy controls using a comprehensive pathway-based approach to assess 207 of the 26 nucleic acid cut repair genes and potential functional SNPs Role in the risk of bladder cancer. The result found, 17