慢性髓细胞性白血病（ChronicMyeloidLeukemia，CML）在细胞遗传学上的特征性改变是Ph染色体（PhiladelphiaChromosome），典型的Ph染色体被认为导致bcr／abl融合基因的产生，是CML的始动突变。那么Ph染色体阴性和（或）变异的Ph染色体的CML患者中是否存在bcr／abl融合基因，他 The characteristic cytogenetic change in chronic myeloid leukemia (CML) is the Philadelphia Chromosome. A typical Ph chromosome is thought to result in the production of the bcr / abl fusion gene, the initiating mutation of CML. Then whether there is a bcr / abl fusion gene in Ph chromosome-negative and / or mutant Ph chromosome CML patients