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目的:研究加味温胆汤联合氨氯地平对痰湿体质高血压患者血清VEGF水平的影响。方法:将110例痰湿体质高血压患者随机分为观察组和对照组各55例,对照组患者给予氨氯地平治疗,观察组患者给予加味温胆汤联合氨氯地平治疗,比较两组患者的血清VEGF水平、中医痰湿体质评分及血压变化情况。结果:两组患者治疗后血压均较治疗前显著改善,且观察组患者改善情况显著优于对照组,差异具有统计学意义(P<0.05);观察组患者治疗后中医痰湿质评分明显低于对照组,差异具有统计学意义(P<0.05);两组患者血清VEGF水平均较治疗前下降,且观察组患者下降更明显,差异具有统计学意义(P<0.05)。结论:采用加味温胆汤联合氨氯地平治疗痰湿体质高血压效果显著,可明显改善患者痰湿体质,降低其血压及血清VEGF水平,改善血管内皮功能,减少心血管不良事件发生,值得临床推广应用。
Objective: To study the effect of Jiaweimin Dan Decoction combined with amlodipine on serum VEGF in phlegm-dampness patients. Methods: One hundred and ten patients with phlegm-dampness were randomly divided into observation group (55 cases) and control group (55 cases). Patients in the control group were treated with amlodipine. The patients in the observation group were treated with Jiawei Wendan Decoction combined with amlodipine. Serum VEGF levels, phlegm constitution score and blood pressure changes. Results: After treatment, the blood pressure of both groups improved significantly, and the improvement in the observation group was significantly better than that in the control group (P <0.05). After treatment, the scores of phlegm-dampness in the observation group were significantly lower In the control group, the difference was statistically significant (P <0.05). The levels of serum VEGF in both groups were lower than those before treatment, and the decrease in the observation group was more obvious. The difference was statistically significant (P <0.05). Conclusion: Modified Wendan Decoction combined with amlodipine can significantly improve the phlegm-dampness constitutional hypertension, can significantly improve the phlegm-dampness constitution, reduce the blood pressure and serum VEGF level, improve the vascular endothelial function and reduce the incidence of cardiovascular adverse events, and is worth clinical Promote the application.