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目的:评估吸入用复方异丙托溴铵溶液佐治儿童肺炎支原体肺炎(MPP)的疗效。方法:选取涿州市妇幼保健院2010年8月至2012年8月收治的MPP患儿62例,随机分为治疗组32例和对照组30例。两组均给予阿奇霉素序贯疗法静脉滴注及退热、化痰等常规治疗,治疗组加用吸入用复方异丙托溴铵溶液雾化吸入治疗。复方异丙托溴铵溶液用法用量:<6岁每次1.25 mL,>6岁每次2.5 mL,6~12 h 1次,每天雾化吸入次数依据患儿咳嗽轻重及夜间睡眠情况调整。结果:治疗组总有效率93.75%,对照组总有效率73.33%,两组比较差异有统计学意义(P<0.05)。咳嗽消失时间治疗组(7.43±1.05)d,对照组(8.10±1.20)d,平均住院时间治疗组(9.11±2.46)d,对照组(11.11±2.75)d,两组比较差异均有统计学意义(P<0.01)。结论:采用吸入用复方异丙托溴铵溶液雾化吸入佐治儿童MPP可促进其临床症状好转,缩短住院时间。
PURPOSE: To evaluate the efficacy of inhaled compound ipratropium bromide in children with mycoplasma pneumoniae pneumonia (MPP). Methods: Sixty-two children with MPP admitted from August 2010 to August 2012 in Danzhou MCH were randomly divided into treatment group (32 cases) and control group (30 cases). Both groups were given azithromycin sequential therapy intravenous infusion and fever, phlegm and other conventional treatment, the treatment group plus inhaled compound ipratropium bromide solution inhalation therapy. Compound ipratropium bromide solution Dosage: <6 years old each 1.25 mL,> 6 years old each 2.5 mL, 6 ~ 12 h 1 times daily inhalation frequency based on children’s cough severity and night sleep conditions adjusted. Results: The total effective rate was 93.75% in the treatment group and 73.33% in the control group, with significant difference between the two groups (P <0.05). There were statistically significant differences between the two groups in the duration of cough disappearance (7.43 ± 1.05) d, control group (8.10 ± 1.20) d, average length of hospital stay (9.11 ± 2.46) days and control group (11.11 ± 2.75) days Significance (P <0.01). Conclusion: The inhalation of compound ipratropium bromide solution inhalation of children with adjuvant treatment of MPP can improve the clinical symptoms and shorten the hospital stay.