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虽然已证实血管扩张药对治疗全身性高血压伴重度左心室衰竭有效,但用于治疗肺动脉高血压伴正常左心室功能的患者,则仅静注或直接注入肺动脉时有效。受益者少而不良反应者多。最近 Rubin 和 Peter报道,短期及长期使用肼笨哒嗪能改善肺动脉高血压病人休息及运动时的血液动力学效应,但作者进行本研究却适得其反。作者对13例患原发性或继发性肺动脉高血压但左心室功能正常的患者,给予肼苯哒嗪,旨在减轻肺血管阻力和临床症状。尽管全身血管阻力显著下降(40%;P<0.001),但肺动脉阻力仅中度下降
Although vasodilators have been shown to be effective in the treatment of systemic hypertension with severe left ventricular failure, patients treated for pulmonary hypertension with normal left ventricular function are only effective when injected intravenously or directly into the pulmonary arteries. Less beneficiaries and adverse reactions were more. Recently, Rubin and Peter reported that short-term and long-term use of hydralazine improved the hemodynamic effects of rest and exercise in patients with pulmonary hypertension, but the authors did the opposite in this study. The authors administered hydralazine to 13 patients with primary or secondary pulmonary hypertension but normal left ventricular function to reduce pulmonary vascular resistance and clinical symptoms. Although systemic vascular resistance decreased significantly (40%; P <0.001), pulmonary artery resistance decreased only moderately