关于痢疾感染的免疫问题,主要由于缺乏适当的动物感染模型,因而研究进展还不大。经口的肠道实验感染一般必须对动物作复杂的预备处理,且在感染后病期甚短,不利于免疫的观察。Sereny氏证明:对未施任何预备处理的正常豚鼠,用痢疾菌作结膜囊的简单 The problem of immunization against diarrhea infection is mainly due to the lack of appropriate animal infection models, so the research progress is not great. Oral intestinal infections generally require complicated preparation of animals, and the disease period after infection is very short, which is not conducive to the observation of immunity. Sereny’s certificate: For the normal guinea pigs without any preliminary treatment, the use of dysentery bacteria for the conjunctival sac