染色体研究能为临床医生提供有关白血病的诊断、分型和预后等方面的重要信息,故已成为一项有价值的实验室检查。但因方法学尚存在不少问题,核型分析有时仍颇感困难。这些问题突出地表现在下述3方面: 1.通常骨髓分裂相较少,有时甚至缺乏;2.染色体往往短小、模糊发毛和分散不良,难以获得优良的显带标本;3.由于制片技术常同时破坏细胞的细胞学和细胞 Chromosome research can provide clinicians with important information on the diagnosis, typing, and prognosis of leukemia and has therefore become a valuable laboratory test. However, there are still many problems in methodology, karyotyping is still sometimes quite difficult. These problems are highlighted in the following three aspects: 1. Generally, there are fewer and sometimes even fewer myelodysplasia; 2. Chromosomes tend to be short, fuzzy hair and poorly distributed, making it difficult to obtain excellent banding specimens; 3. Since the production techniques At the same time destroy cell cytology and cells