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采用具有不同共聚物组成和端基官能团的聚己内酯-b-聚乙二醇共聚物(PCL-b-PEG),通过双乳液溶剂挥发法制备了一系列具有不同表面性质的生物降解高分子微球.采用生物模拟矿化的方法以磷灰石修饰微球表面.进一步通过扫描电镜、热重分析仪、X-射线衍射仪和光电子能谱仪对微球表面磷灰石的形貌、含量、结构和组成进行了分析.研究了微球表面亲水性、粗糙度、官能团以及矿化时间对于磷灰石形成的影响.最终实验结果表明,随着共聚物中PEG含量增加,微球表面粗糙度和亲水性增加,因此微球表面磷灰石含量增加.同时微球表面官能团以及矿化时间的不同也会对磷灰石的形成和分布产生明显影响.
A series of polylactide-b-polyethylene glycol copolymers (PCL-b-PEG) with different copolymer compositions and terminal functional groups were used to prepare a series of biodegradable polymers with different surface properties Molecular microspheres were modified by apatite to modify the surface of the microspheres by means of biomimetic mineralization.The morphologies of apatite on the surface of microspheres were further studied by scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and photoelectron spectroscopy , The content, the structure and the composition of the microspheres were analyzed.The influence of hydrophilicity, roughness, functional groups and mineralization time of the microspheres on the formation of apatite was studied.The final experimental results show that with the increase of PEG content in the copolymer The surface roughness and hydrophilicity of the ball increased, so the content of apatite on the surface of the microsphere increased, and the difference of surface functional groups and mineralization time also had a significant effect on the formation and distribution of apatite.