Landau-Zener Stückelberg (LZS) interference has drawn renewed attention to quantum information processing research because it is not only an effective tool for characterizing two-level quantum systems but also a powerful approach to manipulate quantum states.Superconducting quantum circuits,due to their versatile tunability and degrees of control,are ideal platforms for studying LZS interference phenomena.We use a superconducting Xmon qubit to study LZS interference by parametrically modulating the qubit transition frequency nonlinearly.For dc flux biasing of the qubit slightly far away from the optimal flux point,the qubit excited state population shows an interference patte that is very similar to the standard LZS interference in linear regime,except that all bands shift towards lower frequencies when increasing the rf modulation amplitude.For dc flux biasing close to the optimal flux point,the negative sidebands and the positive sidebands behave differently,resulting in an asymmetric interference patte.The experimental results are also in good agreement with our analytical and numerical simulations.