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目的探讨不同病理类型胃息肉和胃癌中RASAL1基因的表达变化及临床意义。方法对正常胃黏膜组40例、增生性胃息肉组35例、腺瘤性息肉组30例及胃癌组40例采用免疫组化SP染色法检测RASAL1蛋白的表达情况。结果胃癌组RASAL1蛋白的阳性率为17.50%，明显低于正常胃黏膜组（95.00%）、增生性胃息肉组（85.71%）及腺瘤性息肉组（53.33％），差异均有统计学意义（P<0.05）；增生性息肉组中RASAL1蛋白阳性率与性别、年龄、生长部位及息肉大小均无相关性（P<0.05）；腺瘤性息肉组中RASAL1蛋白阳性率与性别、年龄、生长部位均无相关性（P<0.05），而与息肉大小有相关性(P<0.05)。结论检测胃息肉和胃癌中RASAL1基因的表达有助于推测胃息肉的生物学行为发展趋势，从而早期诊断胃癌并判断其预后。“,” Objective To observe the expression of RASAL1 gene in different types of gastric polyp and gastric carcinoma. Methods The expression of RASAL1 gene were examined using immunohistochemical staining in normal gastric mucosa group(n=40) and proliferative polyp group(n=35) and adenomatous polyp group(n=30) and gastric carcinoma group(n=40). Results The positive rates of RASAL1 gene in gastric carcinoma group were obviously lower than that in other groups (P0.05), and were closely relevant to the size of polyp in the adenomatous polyp group (P0.05). Conclusion Detection of RASAL1 gene was helpful to determining the development and biological behavior of gastric polyps, early diagnosis and prognosis of gastric carcinoma.