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目的探讨子宫颈鳞状细胞癌组织中Livin、Caspase-3和ARID的表达变化及临床意义。方法选取南阳市第一人民医院病理科存档的61例子宫颈鳞状细胞癌标本,另选取同时期47例健康子宫颈组织标本为对照组,均以免疫组化法对标本中Livin、Caspase-3和ARID进行检测。观察比较Livin、Caspase-3和ARID与子宫颈鳞状细胞癌临床病理的关系。结果子宫颈鳞状细胞癌中Livin、Caspase-3和ARID阳性检出率均高于对照组;中、高分化Caspase-3阳性表达率高于低分化,差异有统计学意义(χ12=12.140,P<0.05);中、高分化Livin阳性表达率低于低分化,有淋巴结转移Livin阳性表达率高于无淋巴结转移,差异有统计学意义(χ22=9.760,χ32=4.175,均P<0.05);ARID表达与患者临床病理无相关性。结论 Livin、Caspase-3参与子宫颈鳞状细胞癌癌变过程,且与临床病理关系密切。
Objective To investigate the expression of Livin, Caspase-3 and ARID in cervical squamous cell carcinoma and its clinical significance. Methods Totally 61 cases of squamous cell carcinoma of the cervix preserved in pathology department of Nanyang First People’s Hospital were enrolled. 47 cases of healthy cervical tissue specimens of the same period were selected as control group. Immunohistochemistry was used to detect the expression of Livin, Caspase-3 And ARID for testing. The relationship between Livin, Caspase-3, ARID and clinicopathological features of cervical squamous cell carcinoma was observed and compared. Results The positive rates of Livin, Caspase-3 and ARID in cervical squamous cell carcinoma were higher than those in control group. The positive rates of Caspase-3 in well and well-differentiated were higher than those in poorly differentiated (χ 12 = 12.140, P <0.05). The positive rate of Livin in well and well-differentiated Livin was lower than that in poorly differentiated and Lnc lymph node metastasis (χ22 = 9.760, χ32 = 4.175, both P <0.05) There was no correlation between ARID expression and clinical pathology. Conclusion Livin and Caspase-3 are involved in the carcinogenesis of cervical squamous cell carcinoma and have a close relationship with clinical pathology.