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目的:研究肾性贫血与甲状旁腺素(PTH)的相关性。方法:测定122例慢性肾功能衰竭(CRF)患者血PTH,Hb,红细胞压积(Hct),BUN,Cr水平及血透患者促红细胞生成素(EPO)、阿法骨化醇-1a(OH)D3治疗3个月后变化。结果:CRF早期PTH明显升高,中、晚期升高更显著;血PTH与BUN、Cr呈线性正相关(P<0.01),与Ccr、Hb呈线性负相关(P<0.01)。血透患者经EPO、1a(OH)D3治疗3个月后,治疗有效73.7%,无效26.3%。有效组与无效组比较PTH,Hb,Hct均有统计学差异(P<0.01),且PTH下降,Hb,Hct升高。结论:高PTH血症加重贫血且使EPO疗效差,1a(OH)D3能降低高PTH血症,有利于贫血的纠正。
Objective: To investigate the relationship between renal anemia and parathyroid hormone (PTH). Methods: The levels of PTH, Hb, BUN, Cr and the levels of erythropoietin (EPO), alfacalcidol-1 a (OH) in 122 patients with chronic renal failure D3 treatment changes after 3 months. Results: PTH was significantly increased in early stage of CRF, and increased significantly in middle and late stage. There was a linear positive correlation between serum PTH and BUN and Cr (P <0.01), but negatively correlated with Ccr and Hb (P <0.01). Hemodialysis patients treated with EPO, 1a (OH) D3 for 3 months, the treatment of effective 73.7%, 26.3% ineffective. There were significant differences in PTH, Hb and Hct between the effective group and the ineffective group (P <0.01), and PTH decreased and Hb and Hct increased. CONCLUSION: Hypertensive PTH increases anemia and makes EPO less effective. 1a (OH) D3 can reduce high PTH hyperlipidemia, which is good for the correction of anemia.