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】１９９１～１９９７年系统研究了吡虫啉防治稻飞虱、多种作物蚜虫、稻象甲、稻瘿蚊、梨木虱、柑桔潜叶蛾等３０余种重要害虫及７种病毒病的毒理、应用策略和技术，在１９个省（市、区）示范应用３３９．２万ｈｍ２，取得直接经济效益１６．９４亿元，投入产出比达１３１，降低我国防治稻飞虱、蚜虫等用药量的８０％～９５％，并取得从毒理到应用技术多方面的创新。揭示了吡虫啉作用动力学过程中独特的正反馈机制，与害虫中枢神经受体低能态高度竞争性结合的热力学机制，显著的正温效关系，对家蚕无薰蒸毒性以及在植株中的内吸传导特性等。首创吡虫啉低量使用技术，为国外推荐量的１／１０～１／６，发现其高效防治稻瘿蚊、二化螟、小猿叶虫、梨木虱、恶苗病等，发展吡虫啉应急防治稻飞虱高龄种群、种子处理综合防治水稻前中期多种病虫害等关键技术。
From 1991 to 1997, the toxicity of imidacloprid against more than 30 species of major pests and 7 virus diseases, including planthoppers, various crop aphids, rice weevil, rice gall midge, pear psittaci and citrus leafminer, Application of strategies and technologies in 33 provinces (cities, districts) demonstrating the use of 3392000 hm2, achieved direct economic benefits of 1.694 billion yuan, the input-output ratio of 131, reducing the amount of China’s planthopper, aphid and other drugs Of 80% ~ 95%, and made from toxicology to many aspects of applied technology innovation. The thermodynamic mechanism of the unique positive feedback mechanism of imidacloprid kinetic process and its highly competitive binding to the low-energy state of the central nervous system of pests, the significant positive temperature-effect relationship, the non-fumigation toxicity to silkworm, and the systemic absorption Conduction characteristics. The first low-use of imidacloprid technology, recommended for the foreign 1/10 ~ 1/6, found its efficient control of rice gall midge, Chilo suppressalis, small moth leaf pest, pear psylla, Bakana disease, the development of imidacloprid emergency control of rice Planthopper population, Seed treatment Comprehensive prevention and treatment of multiple pests and diseases in the middle and early stages of rice and other key technologies.