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采用D-Gal将大鼠做成实验性肝坏死,分别以ATP及ATP-MgCl_2治疗结果表明,ATP-MgCl_2组无一死亡,[~3H]TdR肝内掺入量与模型组比较有极显著差异(P<9.01),肝坏死程度较轻,在残存的肝细胞浆中肝糖原颗粒和线粒体数量较对照组及ATP组更为丰富,且超过正常组。提示对急性肝坏死尽早使用ATP-MgCl_2,可减轻肝脏坏死程度,并促进肝细胞蛋白质及DNA的合成,从而加速肝细胞的再生和修复。
The rats were treated with D-Gal to make experimental hepatic necrosis. The results of ATP and ATP-MgCl 2 treatment showed that none of the ATP-MgCl 2 groups died, and the [~3H]TdR intrahepatic incorporation amount was significantly higher than that of the model group. The difference (P<9.01) was mild. The number of hepatic glycogen granules and mitochondria in the remaining hepatocyte cytoplasm was more abundant than that in the control group and the ATP group, and it was higher than that in the normal group. The prompt use of ATP-MgCl 2 for acute hepatic necrosis can reduce the degree of hepatic necrosis and promote the synthesis of hepatocyte proteins and DNA, thereby accelerating the regeneration and repair of hepatocytes.