目的探讨骨巨细胞瘤的影像学特点,提高对于骨巨细胞瘤的影像学诊断水平。方法通过对66例经病理确诊的骨巨细胞瘤进行归纳、总结,回顾性分析其放射、CT及部分MRI的影像学特点,并与同影异病的相关疾病进行鉴别与比较。结果本组病例发病年龄在15~58岁之间,发病部位为四肢长骨55例,骶骨10例,胸椎1例;骨质破坏区呈典型的肥皂泡样骨质破坏者为13例,而呈溶骨性骨质破坏者为53例。结论骺板软骨已闭合应作为诊断骨巨细胞瘤的可靠条件之一;发生在四肢长骨骨端的骨巨细胞瘤,应与软骨母细胞瘤、骨囊肿相鉴别;发生在骶骨的骨巨细胞瘤应与脊索瘤、神经源性肿瘤相鉴别;发生在胸椎的骨巨细胞瘤,应与血管瘤、骨转移瘤相鉴别。 Objective To investigate the imaging features of giant cell tumor of bone and to improve the imaging diagnosis of giant cell tumor of bone. Methods Sixty-six patients with giant cell tumor diagnosed by pathology were summarized and retrospectively reviewed. The imaging characteristics of radiotherapy, CT and partial MRI were analyzed retrospectively. Results The incidence of this group of patients aged 15 to 58 years old, the incidence of long limbs limbs in 55 cases, 10 cases of sacrum, thoracic 1 cases; bone destruction area was typical soap bubble-like bone destruction in 13 cases, was Osteolytic osteoporosis were 53 cases. Conclusion Epiphyseal cartilage closed should be considered as one of the reliable conditions for the diagnosis of giant cell tumor of bone. The giant cell tumor of bone that occurs in the long bone of the extremities should be differentiated from chondroblastoma and bone cyst. The giant cell tumor of the sacrum Chordoma and neurogenic tumors should be differentiated; occurred in the thoracic giant cell tumor of bone, hemangiomas and bone metastases should be differentiated.