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小鼠同种异体皮片初次移植,及以后经不同时间再次移植时,排异反应的强度和组织学变化都不相同。初次移植的同种异体皮片,于10天前后呈充血型坏死而被排异。以后间隔10～20天,再植来自同一供者品系的皮片,常出现苍白坏死型排异反应,惟排斥较初植皮片时加速。皮片再植出现苍白坏死型排异反应的时间,与受者经初次皮片移植后血清中同种异体细胞毒性抗体滴度升高的时间相一致。正常受者小鼠接受排异过皮片的小鼠淋巴细胞,或在局部植床周围注射被初次皮片和同种异体淋巴细胞加强致敏的小鼠免疫血清,对有关供者皮片出现加速和增剧的排异反应。而且免疫血清的局部注射,也可引起苍白坏死型排异反应,这些结果提示,后者的发生与同种异体特异性细胞毒性抗体的存在密切有关。
Mouse allogeneic skin graft for the first time, and after repeated transplants at different times, the rejection reaction intensity and histological changes are not the same. Allogeneic skin grafts for the first time were rejected after 10 days as congestion-type necrosis. After an interval of 10 to 20 days, replantation of the skin from the same donor strains, pale necrosis rejection often appear, but exclusion than the initial skin graft acceleration. The timing of the pale necrotic rejection during replantation of the skin coincided with the time of elevated serum allogeneic cytotoxic antibody in the recipient after initial skin grafting. Normal recipient mice receive rejection skinned mouse lymphocytes, or mouse sera immunized with primed skin and allogeneic lymphocytes are primed around the local implant, Accelerate and increase the rejection of the reaction. Moreover, the local injection of immune serum can also cause pale necrotic rejection. These results suggest that the latter is closely related to the existence of alloantigen-specific cytotoxic antibodies.