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目的探讨血浆可溶性OX40L(sOX40L)的水平在急性冠脉综合征(ACS)中的意义及与C反应蛋白(CRP)和血脂的关系。方法按照WHO关于冠心病的诊断标准,并结合冠状动脉造影结果,选择急性心肌梗死(AMI)组25例,不稳定心绞痛(UA)组24例,稳定型心绞痛(SA组)22例,对照组18例。采用酶联免疫吸附法(ELISA)测定标本中的sOX40L水平,并同时测定CRP、血清总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。结果 AMI组sOX40L水平[(14.18±2.75)ng/ml]和UA组sOX40L水平[(13.02±2.92)ng/ml]明显高于SA组[(7.57±2.12)ng/ml]和对照组[(7.77±2.04)ng/ml](P<0.01);sOX40L与CRP,TC/HDL-C均呈显著正相关,与HDL-C呈负相关。结论 AMI和UA组血浆中sOX40L水平明显高于SA组和对照组,且与炎症标志物CRP以及血脂TC/HDL-C呈显著正相关,提示sOX40L有可能作为ACS早期预测的参考指标。
Objective To investigate the significance of plasma soluble OX40L (sOX40L) in acute coronary syndrome (ACS) and its relationship with C-reactive protein (CRP) and serum lipids. Methods According to WHO diagnostic criteria for coronary heart disease and coronary angiography, 25 patients with acute myocardial infarction (AMI), 24 patients with unstable angina (UA), 22 patients with stable angina (SA) 18 cases. The levels of sOX40L in the samples were determined by enzyme-linked immunosorbent assay (ELISA), and the levels of CRP, TC, TG, HDL-C and low density lipoprotein Cholesterol (LDL-C). Results The level of sOX40L in AMI group was significantly higher than that in SA group [(14.18 ± 2.75) ng / ml] and sOX40L level in UA group [(13.02 ± 2.92) ng / ml vs 7.77 ± 2.04 ng / ml] (P <0.01). There was a significant positive correlation between sOX40L and CRP and TC / HDL-C, but negatively correlated with HDL-C. Conclusions The level of sOX40L in AMI and UA groups is significantly higher than that in SA group and control group, and it is positively correlated with CRP and TC / HDL-C, suggesting that sOX40L may be used as a reference index for early prediction of ACS.