NF κB是一种具有多向转录调节作用的蛋白质。它分布广泛 ,并调节多种基因的转录调控 ,参与炎症反应、免疫应答以及细胞的增生、转化和凋亡等重要的生理病理过程。最近研究表明 ,NF κB与中枢神经系统中神经细胞的生长、发育、塑型有关 ,并在急、慢性神经退行性变如脑损伤、脑缺血、癫痫、阿尔茨海默病及帕金森病等病理过程中起重要作用 NF κB is a multi-directional transcriptional regulation of the protein. It is widely distributed and regulates the transcriptional regulation of a variety of genes involved in the inflammatory response, immune response and cell proliferation, transformation and apoptosis and other important physiological and pathological processes. Recent studies have shown that NF-kappaB is involved in the growth, development and plasticity of nerve cells in the central nervous system and is associated with acute and chronic neurodegenerative disorders such as brain damage, cerebral ischemia, epilepsy, Alzheimer’s disease and Parkinson’s disease Other pathological processes play an important role