因严重感染、窒息及颅脑疾病处于应激状态下的新生儿易发生急性胃黏膜病变,引起上消化道出血,使病情加重,造成患儿死亡,有效预防非常重要。西咪替丁(cimetidine)作为预防急性应激性胃黏膜病变的用药虽有研究[1],但报道较少。我院自2000年后开始采用西咪替丁对因严重感染、窒息 Due to severe infection, asphyxia and craniocerebral disease under stress in neonatal prone to acute gastric mucosal lesions, causing upper gastrointestinal bleeding, aggravating the situation, resulting in child mortality, effective prevention is very important. Cimetidine (cimetidine) as a prevention of acute stress gastric mucosal lesions despite the study [1], but less reported. Our hospital since 2000 began using cimetidine due to severe infection, suffocation