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目的:探讨Ⅱ型环氧合酶(Cox-2)和血管内皮生长因子(VEGF)的表达与膀胱移行细胞癌(BTCC)生物学行为的关系。方法:应用免疫组化方法对139例BTCC以及36例正常膀胱组织中的Cox-2和VEGF进行检测。结果:Cox-2的阳性率在T_(a～1)和T_(2～4)分别为34.3%和75.0%(P<0.001);Ⅰ级和Ⅲ级的表达率分别为33.9%和81.8%(P<0.001)。VEGF的阳性表达率在T_(a～1)和T_(2～4)分别为23.9%和79.2%(P<0.001);Ⅰ级和Ⅲ级的表达率分别为32.2%和84.8%(P<0.001)。BTCC组织中COX-2与VEGF表达呈正相关(r=0.607,P<0.05)。结论:Cox-2和VEGF可以作为了解BTCC生物学行为的有效指标。
Objective: To investigate the relationship between the expression of cyclooxygenase Ⅱ (Cox-2) and vascular endothelial growth factor (VEGF) and the biological behavior of transitional cell carcinoma of bladder (BTCC). Methods: Cox-2 and VEGF in 139 cases of BTCC and 36 cases of normal bladder tissue were detected by immunohistochemistry. Results: The positive rates of Cox-2 were 34.3% and 75.0% in T_ (a ~ 1) and T_ (2 ~ 4), respectively. The positive rates of grade Ⅰ and Ⅲ were 33.9% and 81.8% (P <0.001). The positive expression rate of VEGF in T_ (a ~ 1) and T_ (2 ~ 4) were 23.9% and 79.2% respectively (P <0.001). The expression rates of grade Ⅰ and grade Ⅲ were 32.2% and 84.8% 0.001). There was a positive correlation between the expression of COX-2 and VEGF in BTCC (r = 0.607, P <0.05). Conclusion: Cox-2 and VEGF can be used as effective indicators to understand the biological behavior of BTCC.