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在实验研究中已经发现4硝基4’异硫氰基二苯胺对人钩虫有很好疗效。本临床试验包括103例钩虫患者。61%患者有美洲钩虫,39%患者感染十二指肠钩虫。经详细的临床与实验室检查后,将病人分为7组,每组给予不同剂量的治疗方案。治疗后14天用计算粪便中钩虫卵减少百分率来评价各组药物疗效。理想的剂量方案看来是每公斤体重30毫克顿服,此剂量组在驱除两种钩虫中疗效最好(虫卵计数全部阴转),患者的耐受性也较好。
In experimental studies it has been found that 4-nitro 4 'isothiocyanatodiphenylamine has good efficacy against human hookworms. This clinical trial includes 103 hookworm patients. 61% had hookworms and 39% had hookworms. After detailed clinical and laboratory tests, the patients were divided into 7 groups, each given different doses of treatment. Fourteen days after treatment, the percentage of hookworm eggs in the droppings was calculated to evaluate the efficacy of each group of drugs. The ideal dosage regimen appeared to be 30 mg per kg of body weight. This dose group was most effective in expelling both hookworms (all egg counts were negative), and patients were well tolerated.