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目的 :研究胰岛素抵抗与动脉硬化性脑梗死危险因素的关系。方法 :用常规方法测定 91例脑梗死患者和 80例健康人的空腹血糖、胰岛素、血脂、组织型纤溶酶原激活物 (t-PA)、组织型纤溶酶原激活物抑制物 (PAI-1 )和血压水平。结果 :脑梗死组的胰岛素敏感性指数 (ISI)显著低于正常对照组 ,ISI与收缩压、舒张压、TG、APOB、PAI-1水平负相关 ,与 HDL正相关。结论 :胰岛素抵抗与高血压、高 TG、低 HDL血症和高 PAI-1活性等脑梗死危险因素形成密切相关。因此 ,在动脉硬化性脑梗死防治中 ,改善胰岛素敏感性具有重要意义
Objective: To study the relationship between insulin resistance and risk factors of arteriosclerotic cerebral infarction. Methods: The levels of fasting blood glucose, insulin, serum lipids, tissue plasminogen activator (t-PA), tissue plasminogen activator inhibitor (PAI) in 91 patients with cerebral infarction and 80 healthy controls were measured by routine methods -1) and blood pressure level. Results: The insulin sensitivity index (ISI) of cerebral infarction group was significantly lower than that of normal control group. ISI was negatively correlated with systolic blood pressure, diastolic blood pressure, TG, APOB and PAI-1 levels, and was positively correlated with HDL. CONCLUSION: Insulin resistance is closely related to the risk factors of cerebral infarction such as hypertension, hyper TG, hypo HDL, and high PAI-1 activity. Therefore, in the prevention and treatment of arteriosclerotic cerebral infarction, to improve insulin sensitivity is of great significance