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目的观察恩丹西酮联合针刺防治化疗所致恶心与呕吐的疗效。方法 80例血液系统恶性疾病化疗患者随机分为观察组和对照组。每天化疗前 30分钟 ,观察组静注恩丹西酮 8mg ,配合针刺内关、足三里穴 ;对照组单纯静注恩丹西酮 8mg。比较两组化疗 2 4、96小时后的止恶心与止吐疗效及头痛、头晕、便秘和锥体外系症状等恩丹西酮毒副作用发生率。结果观察组控制恶心与呕吐有效率均显著高于对照组 (P <0 .0 1) ;观察组恩丹西酮毒副作用发生率也明显低于对照组 (P <0 .0 1)。结论恩丹西酮配合针刺治疗 ,对化疗所致恶心与呕吐有防治具有协同作用
Objective To observe the efficacy of ondansetron and acupuncture in preventing and treating chemotherapy-induced nausea and vomiting. Methods Eighty patients with hematologic malignancies were randomly divided into observation group and control group. 30 minutes before chemotherapy each day, observation group intravenous ondansetron 8mg, with acupuncture at the customs, Zusanli points; control group intravenous ondansetron 8mg. The incidences of side effects such as headache, dizziness, constipation and extrapyramidal symptoms were compared between two groups after 24,96 hours of chemotherapy. Results The effective rate of nausea and vomiting in the observation group was significantly higher than that of the control group (P <0.01). The incidence of side effects of ondansetron in the observation group was also significantly lower than that of the control group (P <0.01). Conclusion Ondansetron with acupuncture treatment of chemotherapy-induced nausea and vomiting have a synergistic effect