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雄素影响横纹肌的机制还不完全清楚。突出的问题是生理活性类固醇的本质。例如:睾丸酮及其代谢物,5α—二氢睾丸酮,可介导相同组织中不同的反应。本文报导可经睾丸酮芳香化而生成的雌二醇亦对肌肉有直接作用,即增高G_6PD(磷酸戊糖途径的限速酶)的比活性。可见,睾丸酮及其雄素与雌素代谢物都可做为睾丸酮作用于横纹肌的重要的决定性成分。此项观察对性激素与肌肉的相互作用提供了新的资料。 作者给大鼠腹腔注射丙酸睾丸酮或苯甲酸17β-雌二醇。一些大鼠在类固醇处理前
The mechanism by which male hormone affects striated muscle is not fully understood. The outstanding problem is the nature of physiologically active steroids. For example: testosterone and its metabolites, 5α-dihydrotestosterone, can mediate different reactions in the same tissue. This article reports that estradiol, which can be produced by the aromatization of testosterone, also has a direct effect on muscle, increasing the specific activity of G_6PD, the rate-limiting enzyme in the pentose phosphate pathway. Can be seen, testosterone and its male and female metabolites can be used as testosterone role in striated muscle important decisive ingredients. This observation provides new information on the interaction of sex hormones with muscle. The rats were intraperitoneally injected with testosterone propionate or 17β-estradiol benzoate. Some rats before steroid treatment