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目的:比较奥美拉唑与泮托拉唑治疗消化性溃疡出血患者的疗效及不良反应。方法:362例消化性溃疡出血患者随机分为对照组和观察组各181例。对照组予奥美拉唑40 mg+0.9%氯化钠注射液100 ml,ivd,bid;观察组予泮托拉唑80 mg+0.9%氯化钠注射液100 ml,ivd,bid。两组均持续治疗3~6 d。观察记录两组患者呕血、黑便次数、出血情况与出血停止时间;比较两组临床疗效、治疗期间药品不良反应情况和两组药品费用。结果:观察组治疗第1、3 d出血量均明显低于对照组(P<0.05);观察组平均停止出血时间、平均呕血次数及黑便次数也明显低于对照组(P<0.05)。观察组临床有效率为92.27%,对照组为90.61%,两组比较,差异无统计学意义(P>0.05)。观察组日平均费用明显低于对照组(P<0.05)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:消化性溃疡出血患者采用奥美拉唑与泮托拉唑治疗效果相当,均有较高安全性。但泮托拉唑可减少患者呕吐及黑便次数,缩短出血时间,同时治疗费用少。
Objective: To compare the efficacy and side effects of omeprazole and pantoprazole in patients with peptic ulcer bleeding. Methods: 362 patients with peptic ulcer bleeding were randomly divided into control group and observation group of 181 cases. The control group was omeprazole 40 mg + 0.9% sodium chloride injection 100 ml, ivd, bid; observation group was given pantoprazole 80 mg + 0.9% sodium chloride injection 100 ml, ivd, bid. Both groups continued treatment for 3 ~ 6 days. Two groups of patients were observed and recorded vomiting, black stool frequency, bleeding and bleeding time; compare the two groups of clinical efficacy, adverse drug reactions during treatment and two groups of drug costs. Results: The bleeding volume of the observation group was significantly lower than that of the control group on the first and third day (P <0.05). The average stopping bleeding time, the average number of hematemesis and the number of black stools in the observation group were also significantly lower than those in the control group (P <0.05). The clinical effective rate was 92.27% in the observation group and 90.61% in the control group. There was no significant difference between the two groups (P> 0.05). The average daily cost of the observation group was significantly lower than that of the control group (P <0.05). There was no significant difference between the two groups in the incidence of adverse drug reactions (P> 0.05). Conclusion: The treatment of patients with peptic ulcer with omeprazole and pantoprazole has the same effect, both with high safety. However, pantoprazole can reduce vomiting and black stools in patients with shortened bleeding time, while reducing treatment costs.