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目的:系统评价谷胱甘肽S-转移酶P1(glutathione S-transferase P1,GSTP1)基因启动子甲基化与前列腺癌发生风险之间的关系。方法:计算机检索PubMed、Embase、Cochrane Library、ISI Web of Science和中国知网等数据库,按照文献纳入标准和排除标准选择有关GSTP1基因启动子甲基化状态与前列腺癌发生之间关系的研究。对比前列腺癌组织与非前列腺癌组织以及前列腺癌患者与非前列腺癌患者血液或尿液中GSTP1基因启动子甲基化发生率的差异。采用比值比(odds ratio,OR)作为效应量,各效应量以95%可信区间(confidence interval,CI)表示。应用Stata 12.0软件进行Meta分析。结果:最终纳入19项研究,共含1 889例病例。Meta分析结果显示,GSTP1基因启动子甲基化组的前列腺癌发生风险是未甲基化组的23.49倍[OR=23.49(95%CI:13.14~42.01),P<0.001]。结论:GSTP1基因启动子甲基化可能增加前列腺癌的发生风险。
OBJECTIVE: To systematically evaluate the relationship between promoter methylation of glutathione S-transferase P1 (GSTP1) gene and the risk of prostate cancer. Methods: The databases of PubMed, Embase, Cochrane Library, ISI Web of Science and CNKI were searched by computer. The relationship between the methylation status of GSTP1 promoter and the occurrence of prostate cancer was studied according to the inclusion criteria and exclusion criteria. To compare the differences in the promoter methylation of GSTP1 gene in blood or urine between prostate cancer tissues and non-prostate cancer tissues, as well as between prostate cancer patients and non-prostate cancer patients. Odds ratio (OR) was used as the effect amount, and each effect was expressed with a 95% confidence interval (CI). Meta-analysis was performed using Stata 12.0 software. Results: Finally, 19 studies were included, with a total of 1 889 cases. The results of meta-analysis showed that the risk of prostate cancer in GSTP1 promoter methylation group was 23.49 times more than that in unmethylated group [OR = 23.49 (95% CI: 13.14 ~ 42.01, P <0.001]. Conclusion: Methylation of GSTP1 promoter may increase the risk of prostate cancer.