论文部分内容阅读
目的探讨奥氮平治疗脑卒中后抑郁症的疗效及对生活质量的影响。方法 90例脑卒中后抑郁症患者,随机分为对照组和观察组,各45例。对照组给予帕罗西汀治疗,观察组在对照组治疗基础上加用奥氮平治疗。比较两组治疗效果。结果两组治疗前的汉密顿焦虑量表(HAMA)及日常生活能力量表(ADL)评分比较,差异无统计学意义(P>0.05);观察组治疗后优于对照组及治疗前,差异有统计学意义(P<0.05)。治疗后,对照组总有效率为71.1%,观察组总有效率为93.3%,观察组治疗效果优于对照组,差异有统计学意义(P<0.05)。结论奥氮平可有效改善脑卒中后抑郁症患者的抑郁状态及生活质量,提高治疗疗效,效果显著,值得在临床推广应用。
Objective To investigate the efficacy of olanzapine in treating post-stroke depression and its impact on quality of life. Methods 90 patients with post-stroke depression were randomly divided into control group and observation group, 45 cases in each group. The control group was treated with paroxetine. The observation group was treated with olanzapine on the basis of the control group. Compare the treatment effect of two groups. Results There was no significant difference in HAMA and ADL scores between the two groups before treatment (P> 0.05). After treatment, the observation group was better than the control group and before treatment, The difference was statistically significant (P <0.05). After treatment, the total effective rate was 71.1% in the control group, and the total effective rate in the observation group was 93.3%. The treatment effect in the observation group was better than that in the control group, with significant difference (P <0.05). Conclusion Olanzapine can effectively reduce the depression and quality of life of post-stroke depression patients, and improve the curative effect. It is worthy of clinical application.