组织型基质金属蛋白酶抑制剂(tissue inhibitors of matrix metalloproteinase,TIMPs)家族是体内存在的一种天然的基质金属蛋白酶(matrix metalloproteinases,MMPs)抑制剂,主要作用为调节基质金属蛋白酶的功能,并具有调节细胞增殖、血管新生等作用,参与了细胞外基质(extracellular matrix,ECM)更新、重构、机体发育,细胞生长、分化,肿瘤的浸润与转移等多种生理及病理过程。在肿瘤浸润及转移方面,理论上TIMPs能通过抑制MMPs活 Tissue inhibitors of matrix metalloproteinase (TIMPs) family is a kind of natural inhibitors of matrix metalloproteinases (MMPs) in vivo. The main functions of MMPs are to regulate the function of matrix metalloproteinases and to regulate Cell proliferation and angiogenesis. It participates in various physiological and pathological processes such as renewal, remodeling, body development, cell growth, differentiation, tumor invasion and metastasis of extracellular matrix (ECM). In tumor invasion and metastasis, in theory, TIMPs can inhibit MMPs viability