论文部分内容阅读
目的：探讨甲状旁腺激素（ｐａｒａｔｈｙｒｏｉｄ ｈｏｒｍｏｎｅ，ＰＴＨ） 对人牙乳头间充质细胞生物学特性的影响。方法：放射免疫学方法。结果：ＰＴＨ 在１ ～５ｍｉｎ 内可增加人牙乳头间充质细胞ｃＡＭＰ 合成，且有浓度依赖性；单独加入０．２ｍ ｍｏｌ／Ｌ 异丁基甲基黄嘌呤（ＩＢＭＸ） 后，对ｃＡＭＰ含量的影响很小；加入０．２ｍ ｍｏｌ／ＬＩＢＭＸ＋ＰＴＨ 后，ｃＡＭＰ含量比单独加入ＰＴＨ 增加更加显著，作用可持续１５ｍｉｎ 。结论：ＰＴＨ 有可能通过增强人牙乳头间充质细胞内ｃＡＭＰ合成，影响细胞其它的生物学特性。
Objective: To investigate the effect of parathyroid hormone (PTH) on the biological characteristics of human dental papilla mesenchymal cells. Methods: Radiological immunological methods. Results: PTH increased cAMP synthesis in human dental papilla mesenchymal cells in a concentration range of 1 ~ 5 min, and the concentration of cAMP was significantly increased after adding 0.2 μmol / L isobutylmethylxanthine (IBMX) alone Small; adding 0.2m mol / LIBMX + PTH, cAMP content increased more significantly than PTH alone, the role of sustainable 15min. Conclusion: PTH may affect cAMP synthesis in human dental papilla mesenchymal cells and affect other biological characteristics of cells.