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目的 探讨彩色多普勒超声心动图对评价新生儿缺氧性肺动脉高压 (PAH)左室重塑和舒张功能 (LVDF)减低的临床意义。 方法 对彩色多普勒超声心动图证实的 2 4例继发有PAH的呼吸系统疾病新生儿与 14例无PAH的呼吸系统疾病新生儿的多普勒超声心动图资料进行对比分析。 结果 与对照组相比 ,肺动脉收缩压增高组的左室舒张末内径 (19.74± 0 .71)mm比 (14 .4 2±0 .32 )mm、右室内径 (11.92± 2 .18)mm比 (7.34± 0 .93)mm、肺动脉内径 (10 .2 0± 1.2 1)mm比(6 .89± 0 .2 2 )mm明显增大 (P <0 .0 5 ) ,三尖瓣返流 (2 .4 1± 0 .80 )m/s流速增快及肺动脉收缩压力(38.2 3± 3.2 6 )mmHg升高 ,差异均有显著性 (P <0 .0 5 ) ,与对照组相比 ,室间隔增厚不明显 ,且缺氧组肺动脉收缩压增高的二尖瓣口血流多普勒频谱A峰流速 (80 .5 6± 2 1.78)m/s比 (4 9.17± 2 3.97)m/s、A峰流速速度时间积分 (7.4 1± 1.2 3)s比 (3.94± 1.85 )s及AV/EV(0 .89± 0 .12 )比 (0 .5 1±0 .16 )、AVT/EVT (0 .84± 0 .2 9)比 (0 .4 1± 0 .2 1) ,与对照组相比均逐渐明显增大 (P <0 .0 1) ;左室等容舒张时间 (77.2 6± 2 4 .32 )s比 (5 2 .31± 2 8.0 6 )s延长 ,但与对照组相比无差异无显著性 (P >0 .0 5 ) ,且E峰流速 (99.2 5± 3
Objective To investigate the clinical significance of color Doppler echocardiography in assessing the reduction of left ventricular remodeling and diastolic function (LVDF) in neonates with hypoxic pulmonary hypertension (PAH). Methods Doppler echocardiography data of 24 neonates with PAH secondary to respiratory diseases confirmed by color Doppler echocardiography and 14 neonates without PAH respiratory diseases were compared and analyzed. Results Compared with the control group, left ventricular end diastolic diameter (19.74 ± 0.71) mm (14.42 ± 0.32) mm, right ventricular internal diameter (11.92 ± 2.18) mm (7.34 ± 0.93) mm, pulmonary artery diameter (10.2 ± 1.2 1) mm (6.989 ± 0.222) mm significantly increased (P <0.05), tricuspid regurgitation (2 .4 ± 0.80) m / s and pulmonary systolic pressure (38.2 3 ± 3.2 6) mmHg were significantly higher than those in the control group (P <0.05) (P <0.05), and the ventricular septal thickening was not obvious, and the pulmonary artery systolic pressure in the anoxia group was significantly higher than that of the mitral valve at peak velocity (80.56 ± 2 1.78) m / s (4 9.17 ± 2. 3.97 (7.41 ± 1.2 3) s (3.94 ± 1.85) s and AV / EV (0.89 ± 0.12) vs (0.51 ± 0.16) m / , AVT / EVT (0.84 ± 0.29), (0.4 ± 0.21), all increased gradually compared with the control group (P <0.01) (77.26 ± 2.42.32 s) was significantly longer than that of the control group (P <0.05), and the E peak velocity (99.2 5 ± 3