目的探讨白细胞、C-反应蛋白(CRP)和血糖联合检测对手足口病患儿早期诊断的意义。方法172例手足口病患儿及同期82例急性上呼吸道感染的患儿入院时和入院第四天分别检测血白细胞和CRP及血糖。结果普通组和重症组治疗后CRP下降明显,诊疗前后差异有统计学意义(P<0.05),重症组白细胞、血糖治疗后下降不明显,差异无统计学意义(P>0.05)。结论对手足口病患儿白细胞、CRP与血糖三者同时检测,可取得最佳的临床诊断价值。 Objective To investigate the significance of the combined detection of leucocyte, C-reactive protein (CRP) and blood sugar in the early diagnosis of hand-foot-mouth disease in children. Methods A total of 172 children with HFMD and 82 children with acute upper respiratory tract infection during the same period were enrolled in the study. Blood leucocytes, CRP and blood glucose were detected on admission and on the fourth day of admission. Results The CRP decreased obviously in general group and severe group after treatment, the difference was statistically significant before and after the treatment (P <0.05). There was no significant difference between the severe group and the control group (P> 0.05). Conclusion The detection of white blood cells, CRP and blood sugar in children with hand-foot-mouth disease at the same time can achieve the best clinical diagnostic value.