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英格兰东北地区甲亢患者的发病率女性为1.9%,男性为0.19%,虽数字不太精确,但说明Graves病系最普遍的自身免疫性疾病之一。目前,认为Graves病中的甲亢表现及甲状腺肿是结合在甲状腺细胞膜上一种特殊的免疫球蛋白作用所致。这些免疫球蛋白有不同的命名,但以促甲状腺激素(TSH)受体抗体最为合适,因其模拟促甲状腺激素的刺激作用,可促使环一磷酸腺苷产生,放射性碘摄取以及胶质小滴形成。
The incidence of hyperthyroidism in northeastern England was 1.9% for women and 0.19% for men. Although the figures are not accurate, it shows that Graves’ disease is one of the most common autoimmune diseases. Currently, it is thought that the manifestation of hyperthyroidism in Graves’ disease and goiter are the result of a special immunoglobulin that binds to the thyroid cell membrane. These immunoglobulins have different names but are best suited for thyrotropin (TSH) receptor antibodies because they mimic thyroid-stimulating stimuli, which can promote adenosine monophosphate production, radioiodine uptake, and glial droplets form.