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测定了５８例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）病人及４８例正常人的血浆Ｌｐ（ａ）、ＡｐｏＡ１和ＡｐｏＢ浓度。ＮＩＤＤＭ并发大血管病变组与无血管病变组比较，Ｌｐ（ａ）浓度升高，差异极显著，ＡｐｏＢ升高显著（Ｐ＜０．０５），ＡｐｏＡ１降低显著（Ｐ＜０．０１）。血浆Ｌｐ（ａ）与ＡｐｏＡ１、ＡｐｏＢ无显著相关性。提示Ｌｐ（ａ）、ＡｐｏＡ１、ＡｐｏＢ异常都是ＮＩＤＤＭ大血管病变的危险因素之一。
Plasma concentrations of Lp (a), ApoA1 and ApoB were measured in 58 non-insulin dependent diabetes mellitus (NIDDM) and 48 healthy controls. The concentration of Lp (a) in NIDDM complicated macroangiopathy group was significantly higher than that in non-vascular disease group (P <0.05), ApoA1 decreased significantly (P <0.01). There was no significant correlation between plasma Lp (a) and ApoA1 and ApoB. It is suggested that Lp (a), ApoA1 and ApoB abnormalities are all risk factors of NIDDM macroangiopathy.