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21例先天性心脏病室间隔缺损合并肺动脉高压患儿,术后给予氨力农5～10μg/(kg·min)微泵静脉持续滴注,观察其临床疗效。用药前后的血、尿常规,肝、肾功能无明显变化。肺动脉压力正常组PVRI下降了29％(P<0.05);肺动脉高压组mPAP、PVRI、Rp/Rs分别下降了17％、21％、15％(P<0.05)。两组患儿的CI、SI均显著增加。同时,患儿四肢末梢转暖,尿量增加,肝脏缩小。本实验结果表明,氨力农具有正性肌力、外周血管扩张以及改善心室舒张功能的作用。氨力农的选择性扩张肺血管作用取决于患儿的肺动脉压力和肺血管阻力的大小。
Twenty-one children with congenital heart disease and ventricular septal defect complicated with pulmonary hypertension were given continuous infusion of 5 ~ 10 μg / (kg · min) aminopterin intravenously to observe the clinical curative effect. Before and after treatment of blood, urine, liver, kidney function no significant change. The PVRI decreased by 29% (P <0.05) in patients with normal pulmonary hypertension and mPAP, PVRI and Rp / Rs decreased by 17%, 21% and 15% (P <0.05) in patients with pulmonary hypertension. CI and SI in both groups increased significantly. At the same time, children with extremities warm, urine output increased, the liver narrowed. The experimental results show that ammonia force farmers have positive inotropic, peripheral vasodilatation and improve ventricular diastolic function. Selective expansion of amrinone Pulmonary vascular function depends on the size of pulmonary artery pressure and pulmonary vascular resistance in children.