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目的观察褪黑素对高脂饮食大鼠脂肪肝的影响。方法将50只雄性Wistar大鼠随机分成5组:正常对照组、模型组和低、中、高3个剂量褪黑素组。采用喂饲高脂饲料复制大鼠脂肪肝模型。褪黑素组分别在造模同时以褪黑素2.5mg/(kg·d)、5.0mg/(kg·d)和10.0mg/(kg·d)剂量腹腔注射进行干预。12周后观察血清ALT、AST、血清及肝匀浆中总胆固醇(Tch)、甘油三酯(TG)以及肝脏指数和肝脏病理形态学的变化。结果与模型组相比,高剂量褪黑素组血清AST水平明显下降(P<0.01),中、高剂量褪黑素组肝指数、肝内Tch和TG明显降低(P<0.05,P<0.01)。中、高剂量褪黑素组大鼠肝脏病理变化明显减轻(P<0.001),以高剂量组更明显。结论褪黑素可明显减轻高脂饮食诱导的大鼠脂肪肝,且与剂量有一定关系。
Objective To observe the effect of melatonin on fatty liver in high fat diet rats. Methods Fifty male Wistar rats were randomly divided into 5 groups: normal control group, model group and low, medium and high doses of melatonin. Rat model of fatty liver was reproduced by feeding high fat diet. The melatonin group was intraperitoneally injected with melatonin 2.5 mg / (kg · d), 5.0 mg / (kg · d) and 10.0 mg / (kg · d) respectively during modeling. After 12 weeks, the serum ALT, AST, total cholesterol (Tch), triglyceride (TG), liver index and pathological changes of liver in serum and liver homogenate were observed. Results Compared with the model group, serum AST level was significantly decreased in the high dose of melatonin group (P <0.01), liver index and Tch and TG in the middle and high dose of melatonin group were significantly decreased (P <0.05, P <0.01 ). The pathological changes of liver in middle and high dose melatonin groups were significantly relieved (P <0.001), especially in high dose group. Conclusion Melatonin can significantly reduce the fatty liver induced by high-fat diet in rats, and has some relationship with the dose.