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目的研究纤溶指标D-二聚体(D-dimer,D-D)抗原含量在急性脑梗死(CI)、脑出血(CH)及短暂性脑缺血发作(TIA)患者血浆中治疗前后的变化及其临床意义。方法用酶联免疫吸附双抗体夹心法(ELISA)分别检测30例脑梗死、20例脑出血及15例短暂性脑缺血发作(TIA)患者治疗前后血浆D-二聚体的抗原含量水平并分别与对照组比较。结果脑梗死、脑出血急性期血浆D-二聚体水平均高于对照组,两组之间差异无统计学意义;治疗后两组D-二聚体含量降低,TIA组D-二聚体含量变化无统计学意义。结论血浆D-二聚体是反映体内纤溶状态、纤溶活性的重要指标,在不同的疾病和病期有不同的变化,可作为判断病情严重程度、预后与复发及判断病程、病期的参考指标;D-二聚体单独应用不能鉴别急性脑梗死和脑出血。
Objective To study the plasma levels of fibrinolytic D-dimer (D-dimer, DD) in patients with acute cerebral infarction (CI), cerebral hemorrhage (CH) and transient ischemic attack (TIA) Its clinical significance. Methods The antigen levels of plasma D-dimer in 30 patients with cerebral infarction, 20 patients with cerebral hemorrhage and 15 patients with transient ischemic attack (TIA) were detected by enzyme-linked immunosorbent assay (ELISA) Respectively compared with the control group. Results The levels of plasma D-dimer in acute stage of cerebral infarction and cerebral hemorrhage were all higher than those of the control group. There was no significant difference between the two groups after treatment. The D-dimer levels of both groups decreased after treatment, but D-dimer No significant change in content. Conclusion Plasma D-dimer is an important index reflecting fibrinolytic activity and fibrinolytic activity in vivo. It has different changes in different diseases and stages, which can be used to judge the severity of the disease, prognosis and recurrence and to determine the course of the disease, the stage of disease Reference index; D-dimer alone can not identify acute cerebral infarction and cerebral hemorrhage.