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目的探讨茵栀黄口服液联合微生态制剂妈咪爱辅助新生儿黄疸治疗的临床疗效和安全性以及对免疫功能的影响。方法选取鹰潭市人民医院收治的新生儿黄疸150例,按随机数字表法分为2组:对照组81例采用常规治疗;治疗组69例在常规治疗的基础上口服茵栀黄口服液以及微生物制剂妈咪爱治疗。比较2组治疗有效率、治疗后血清总胆红素和免疫功能变化,以及不良反应发生情况。结果治疗组有效率显著高于对照组;治疗组在治疗后第7 d,血清胆红素水平显著低于对照组,免疫功能相关指标优于对照组,2组比较差异均有统计学意义(均P<0.05);2组患儿均无严重不良反应发生。结论茵栀黄口服液联合微生态制剂妈咪爱辅助治疗新生儿黄疸效果明显,可显著改善患儿免疫系统功能,疗效好,且无明显不良反应,可作为新生儿高胆红素血症辅助治疗药物。
Objective To investigate the clinical efficacy and safety of Yinzhihuang Oral Liquid combined with probiotics mommy in the treatment of neonatal jaundice and its effects on immune function. Methods 150 cases of neonatal jaundice admitted to Yingtan People’s Hospital were divided into two groups according to random number table method: control group (n = 81) received routine treatment; treatment group (n = 69) received Yinzhihuang oral liquid and micro-organism Formulation Mommy love treatment. The therapeutic efficacies of two groups were compared, the changes of serum total bilirubin and immune function after treatment, and the occurrence of adverse reactions. Results The effective rate of the treatment group was significantly higher than that of the control group. On the 7th day after treatment, the serum bilirubin level in the treatment group was significantly lower than that in the control group, and the indexes related to immune function were superior to those in the control group. The differences between the two groups were statistically significant All P <0.05). No serious adverse reactions occurred in both groups. Conclusion Yinzhihuang oral liquid combined with micro-ecological preparation Mommy love assisted treatment of neonatal jaundice significantly, can significantly improve children’s immune system function, good effect, and no obvious adverse reactions, can be used as a supplement to neonatal hyperbilirubinemia medicine.