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目的:探讨衢州市普通人群不同年龄妇女人乳头瘤病毒(HPV)感染状况和感染型别,为宫颈癌的防治提供理论依据。方法:对1 003例衢州市不同年龄的妇女宫颈分泌物予通用引物PCR和HPV G enoA rray-test同步检测,PCR-RFLP用于补充。结果:1 003例妇女中共检出HPV阳性142例,占14.16%,其中单一感染118例,占11.76%;双重及以上感染24例,占2.39%;142例阳性患者中有高危型HPV感染的为122例,占HPV总阳性人数的85.91%。阳性患者中高危型以52、58、16为主,检出率分别为3.68%、1.79%、1.49%。不同年龄组(<25,25～,30～,35～,40～,45～,≥50)的HPV感染率分别为34.56%、23.66%、12.09%、11.66%、10.19%、11.18%、9.09%,随年龄增长有下降趋势,但经统计学检验差异无显著性(2χ=0.00,P>0.05)。农村与城市各年龄段感染率经统计学检验差异无显著性(χ2=0.00,P>0.05)。HPV感染高峰年龄在<30岁(4.99%)。结论:衢州普通人群各年龄段妇女HPV感染均有一定比例,且高危型HPV感染率在总阳性患者中所占比例较高。因此,有必要定期对健康妇女进行HPV感染筛查,作为宫颈癌的初筛手段;并进行随访和相应治疗,以降低宫颈癌的发病风险。
Objective: To investigate the status of human papillomavirus (HPV) infection and the type of infection in women of different ages in Quzhou general population and to provide theoretical basis for the prevention and treatment of cervical cancer. Methods: One hundred and three cases of cervical secretions from women of different ages in Quzhou were detected by universal primer PCR and HPV G enoAray-test simultaneously, and PCR-RFLP was used for the supplement. Results: Of the 1 003 women, 142 were positive for HPV infection, accounting for 14.16%, of which 118 were single infection, accounting for 11.76%; 24 were double and above, accounting for 2.39%; 142 were positive for HPV infection 122 cases, accounting for 85.91% of the total number of HPV positive. Among the positive patients, the high-risk patients were mainly 52, 58 and 16, with the detection rates of 3.68%, 1.79% and 1.49% respectively. The HPV infection rates of different age groups (<25,25 ~, 30 ~, 35 ~, 40 ~, 45 ~, ≥50) were 34.56%, 23.66%, 12.09%, 11.66%, 10.19%, 11.18%, 9.09 %, Decreased with age, but no statistically significant difference (2χ = 0.00, P> 0.05). There was no significant difference in infection rates between rural and urban areas by statistical test (χ2 = 0.00, P> 0.05). The peak age of HPV infection was <30 years old (4.99%). Conclusion: There is a certain proportion of HPV infection among women of all ages in Quzhou general population, and the high-risk HPV infection rate is higher in the total positive patients. Therefore, it is necessary to carry out regular screening of healthy women for HPV infection as a screening method for cervical cancer; and follow-up and the corresponding treatment to reduce the risk of cervical cancer.