血栓性血小板减少性紫癜(TTP)是一种因溶血性贫血、血小板减少及微血栓形成而导致多器官损害的血栓性微血管病。临床上主要表现为病情较凶险、进展快、病死率高,可高达80%~90%。有研究显示~([1]),在支持对症处理的基础上对患者早期采取血浆置换,可以将患者的生存率提高到75%~92%。该病成人中研究相对较多,儿童研究相对较少,以下通过2例典型病例及文献复习进一步加强对该病的认识, Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microvascular disease that causes multiple organ damage due to hemolytic anemia, thrombocytopenia and microthrombus formation. The main clinical manifestations of the disease more dangerous, fast progress, high mortality, up to 80% to 90%. Some studies have shown that ~ ([1]), in support of the symptomatic treatment of patients based on early plasma exchange, the patient’s survival rate can be increased to 75% to 92%. The disease is relatively large in adult studies, children are relatively small, the following through 2 cases and literature review to further strengthen the understanding of the disease,