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本文报告35例静脉滴注甲氰咪胍治疗急性上消化道出血,在用药后24～48小时内出血停止者31例,有效率为88.6%。该药拮抗组织胺刺激壁细胞泌酸,对胃泌素和兴奋迷走神经所致的壁细胞泌酸也有较强的抑制作用。用药后胃液中H~+浓度减少和pH增高,从而阻止了氢离子向胃粘膜内扩散造成的胃粘膜进一步损害,同时胃酸分泌减少可使胃蛋白酶活性降低而
This article reports 35 cases of intravenous cimetidine treatment of acute upper gastrointestinal bleeding, bleeding within 24 to 48 hours after treatment in 31 cases, the effective rate was 88.6%. The drug antagonizes histamine to stimulate parietal oxytocin, gastric acid secretion and excitatory vagus nerve cell wall acid secretion also has a strong inhibitory effect. H ~ + concentration in gastric juice decreased and pH increased after treatment, which prevented further damage of gastric mucosa caused by the diffusion of hydrogen ions into the gastric mucosa. At the same time, decreased gastric acid secretion decreased pepsin activity