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目的:探讨脐血干细胞治疗失代偿期肝硬化的疗效研究。方法:选取2014年12月至2015年9月在某院接受治疗的45例肝硬化失代偿期患者,采取静脉输注的途径移植脐血干细胞,观察比较移植前后患者血清丙氨酸氨基转移、总胆红素、凝血酶原时间以及清蛋白水平变化情况。结果:移植后患者的血清丙氨酸氨基转移、总胆红素、凝血酶原时间以及清蛋白(59.45±5.03 U/L、35.46±1.03μmol/L、18.26±1.62 s、20.36±4.51g/L)都明显的低于移植前(78.56±12.03 U/L、45.13±4.12μmol/L、20.13±5.16 s、29.15±2.16 g/L),患者移植前后指标变化情况比较,差异具有统计学意义(P<0.05)。结论:脐血干细胞移植是临床上治疗失代偿期肝硬化的一种比较安全有效的方法,可以起到肝脏支持的作用。
Objective: To investigate the therapeutic effect of umbilical cord blood stem cells on decompensated cirrhosis. Methods: Forty-five patients with decompensated cirrhosis who were treated in a hospital from December 2014 to September 2015 were enrolled in this study. Umbilical cord blood stem cells were transplanted by intravenous infusion. The levels of serum alanine aminotransferase , Total bilirubin, prothrombin time, and albumin levels. Results: Serum alanine aminotransferase, total bilirubin, prothrombin time and albumin (59.45 ± 5.03 U / L, 35.46 ± 1.03μmol / L, 18.26 ± 1.62 s, 20.36 ± 4.51g / L) were significantly lower than those before transplantation (78.56 ± 12.03 U / L, 45.13 ± 4.12μmol / L, 20.13 ± 5.16 s, 29.15 ± 2.16 g / L), and the difference was statistically significant (P <0.05). Conclusion: Umbilical cord blood stem cell transplantation is a safe and effective method for the treatment of decompensated cirrhosis. It can play a role of liver support.