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目的:评价利尿剂(双氢克尿噻)及与钙拮抗剂(尼群地平)合用对原发性高血压(EH)患者血脂的影响。方法:针对社区EH患者,应用双氢克尿噻2周,根据血压达标情况加用尼群地平(A组,68例),或继续维持小剂量双氢克尿噻(B组,67例)治疗,随访3个月,观察2组用药前后血压、心率、血脂的变化。结果:2组患者经治疗后血压、心率均有所下降(P<0.05～0.01);3个月末B组TC、TG、LDL-C、HDL-C无变化(P>0.05),A组用药后TC降低(P<0.01)。2组间TC、TG、LDL-C、HDL-C变化差异无统计学意义(P>0.05)。结论:钙拮抗剂与利尿剂联合应用治疗EH患者对血脂无不利影响。
Objective: To evaluate the effects of diuretic (hydrochlorothiazide) and calcium antagonist (nitrendipine) on blood lipids in patients with essential hypertension (EH). Methods: Community-based EH patients were treated with hydrochlorothiazide for 2 weeks. Nitricarbazepine (group A, n = 68) was given according to the standard of blood pressure, or a small dose of hydrochlorothiazide (group B, n = 67) Treatment, followed up for 3 months, observed two groups before and after treatment of blood pressure, heart rate, blood lipids changes. Results: After treatment, the blood pressure and heart rate decreased in both groups (P <0.05-0.01). There was no change in TC, TG, LDL-C and HDL-C levels in group B at the end of 3 months (P> 0.05) After TC decreased (P <0.01). There were no significant differences in TC, TG, LDL-C and HDL-C between the two groups (P> 0.05). Conclusion: The combination of calcium antagonist and diuretic has no adverse effect on blood lipids in EH patients.