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目的:探讨甲状腺自身抗体在不同免疫性甲状腺疾病中的临床意义。方法:收集2005年1月至2011年9月在东莞东华医院行甲状腺手术且术后病理证明是Graves病(GD)、桥本甲状腺炎(HT)患者59例,比较在不同甲状腺疾病中抗甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)水平及其与甲状腺功能的关系。结果:两组TPOAb、TgAb水平显示超敏促甲状腺素(sTSH)升高组TPOAb水平明显高于sTSH非升高组,两组TgAb水平差异无统计学意义。Spearman相关分析显示TPOAb与sTSH正相关,与血清游离甲状腺素(FT4)、血清游离三碘甲腺原氨酸(FT3)、病程无相关性;TgAb与sTSH、FT4、FT3、病程无相关性。结论:病史长的GD患者TPOAb水平明显升高。HT患者sTSH升高组的TPOAb水平明显高于sTSH非升高组,TPOAb与sTSH成正相关。
Objective: To investigate the clinical significance of thyroid autoantibodies in different immune thyroid diseases. Methods: Thyroid surgery was performed at Donghua Hospital of Dongguan from January 2005 to September 2011 and 59 patients with Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) were pathologically proved to have anti-thyroid disease Thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb) levels and its relationship with thyroid function. Results: The levels of TPOAb and TgAb in both groups showed that TPOAb level in hypersensitive thyroid-stimulating hormone (sTSH) group was significantly higher than that in sTSH non-elevating group, and there was no significant difference between the two groups in TgAb level. Spearman correlation analysis showed that TPOAb was positively correlated with sTSH, and had no correlation with serum free thyroxine (FT4), serum free triiodothyronine (FT3), duration of disease. There was no correlation between TgAb and sTSH, FT4, FT3. Conclusion: TPOAb levels in patients with long history of GD were significantly higher. HTOA patients with elevated sTSH TPOAb levels were significantly higher than sTSH non-elevated group, TPOAb and sTSH into a positive correlation.