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目的评价综合干预对代谢综合征(MS)高危人群心血管危险因素的影响。方法对经常住院的100例MS高危人群(干预组)进行综合干预,随访2年。另选一般临床资料与干预组相匹配的60例由于工作繁忙无时间进行系统干预的MS高危人群作为对照组。观察两组患者干预前后的腰围、体质指数(BMI)、收缩压(SBP)和舒张压(DBP)、高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)和C-反应蛋白(CRP)的变化。结果干预前两组患者腰围、BMI、SBP、DBP、HDL-C、LDL-C、TG、FBG、FINS、HOMA-IR、CRP水平间差别无统计学意义(P>0.05)。干预后两组患者除LDL-C和TG外,其他各项检测指标间差别均有统计学意义(P<0.05)。结论综合干预可改善MS高危人群的肥胖,降低血压和血糖,增加HDL-C水平,降低胰岛素抵抗和CRP水平。
Objective To evaluate the effect of comprehensive intervention on cardiovascular risk factors in high-risk population of metabolic syndrome (MS). Methods A total of 100 high-risk MS patients (intervention group) who were hospitalized frequently were followed up for 2 years. In addition, 60 cases of high-risk MS patients who did not have time for system intervention were selected as the control group. The changes of waist circumference, body mass index (BMI), SBP and DBP, HDL-C, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), fasting insulin (FINS), insulin resistance index (HOMA-IR) and C-reactive protein (CRP) Results There was no significant difference in waist circumference, BMI, SBP, DBP, HDL-C, LDL-C, TG, FBG, FINS, HOMA-IR and CRP between the two groups before intervention (P> 0.05). Except for LDL-C and TG, there were significant differences between the other indexes in two groups after intervention (P <0.05). Conclusion The comprehensive intervention can improve the obesity, blood pressure and blood sugar, increase the level of HDL-C, decrease the level of insulin resistance and CRP in MS high risk population.