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慢性淋巴细胞性白血病(CLL)患者发生弥漫性组织细胞淋巴瘤,Richter’s 综合征是罕见的,然而它是一个特殊的临床病理现象。本文作者报告Richter’s 综合征的5个新病例和总结另外41资料。从3组资料说明 CLL 患者弥漫性组织细胞淋巴瘤的发病率为3~10%。这些以后发展成弥漫性组织细胞淋巴瘤的46例患者无慢淋白血病的特征,而这点能与从未发生弥漫性组织细胞淋巴瘤的典型的慢淋白血病
Diffuse histiocytic lymphoma occurs in patients with chronic lymphocytic leukemia (CLL), and Richter’s syndrome is rare, however, it is a specific clinical pathology. The authors report five new cases of Richter’s syndrome and summarize another 41 data. From 3 sets of data shows that the incidence of diffuse histiocytic lymphoma in CLL patients is 3 to 10%. Of these 46 patients who subsequently developed diffuse histiocytic lymphoma, they did not have the characteristics of CLL, and this is consistent with that of a typical chronic lymphocytic leukemia that has never had a diffuse histiocytic lymphoma