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卵母细胞成熟的调控机制,胚胎的发育与分化是生殖机理研究中最重要而尚不够清楚的问题。自Pincus和Enzmann首次体外培养卵母细胞成功以来,体外受精已在家畜和人类的研究中取得很大进展。尽管世界上已有超过5000名“试管婴儿”诞生,但进一步的研究受伦理、法律和实验条件的限制。基于非人灵长类在生理上与人类的极其相似的特征,非人灵长类的体外受精的研究不仅是解决人类的不育,也是解决受精机制(包括精、卵的成熟调控)、胚胎发育、植入和遗传病理最有效的工具。卵母细胞的成熟是体外受精的首要问题,它可能受到
The regulatory mechanism of oocyte maturation, embryonic development and differentiation of reproductive mechanism is the most important and not yet clear enough. In vitro fertilization has made great strides in the study of livestock and humans since the first successful culturing of oocytes in vitro by Pincus and Enzmann. Despite the birth of over 5,000 “IVF” in the world, further research is limited by ethical, legal and experimental conditions. Based on the physiologically similar characteristics of non-human primates to humans, studies on in vitro fertilization of non-human primates not only address human infertility, but also solve the mechanism of fertilization (including the regulation of fine and egg maturation), the embryo Development, implantation and genetic pathology the most effective tool. Oocyte maturation is the primary problem of in vitro fertilization and it may be affected