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目的:探讨胃癌微淋巴管密度(LMVD)与侵袭转移的相关性。方法:应用免疫组化SP法检测胃癌组织和正常胃组织淋巴管内皮细胞透明质酸受体-1(LYVE-1)的表达,并计数LMVD,分析LMVD与侵袭转移的关系。结果:胃癌组织癌周区处于开放状态的功能性微淋巴管明显增多。胃癌组织LMVD较正常胃组织LMVD增多,差异有统计学意义(P<0.05)。有淋巴结转移胃癌中LMVD明显多于无淋巴结转移者,直径≥5cm胃癌LMVD明显多于直径<5cm者,侵及浆膜胃癌组织LMVD明显多于未侵及浆膜者,差异均有统计学意义(P<0.05)。结论:胃癌组织LMVD与肿瘤大小、浸润深度和淋巴转移有密切关系,可以作为肿瘤诱导生成淋巴管研究的量化指标,有助于胃癌的预后判断及治疗方案的评价。
Objective: To investigate the relationship between lymphatic vessel density (LMVD) and invasion and metastasis in gastric cancer. Methods: The expressions of hyaluronan receptor-1 (LYVE-1) in lymphatic endothelial cells of gastric cancer and normal gastric tissues were detected by immunohistochemical SP method. The relationship between LMVD and the invasion and metastasis was analyzed by LMVD. Results: There was a significant increase of functional lymphatic vessels in the pericancerous area of gastric cancer. The LMVD of gastric cancer tissue was higher than that of normal gastric tissue, the difference was statistically significant (P <0.05). There were significantly more LMVD in lymph node metastasis than those without lymph node metastasis, and the diameter of LMVD was more than 5cm in diameter than 5cm in diameter, and there were significant differences in LMVD between serosal invasion and serosal invasion (P <0.05). Conclusion: The expression of LMVD in gastric carcinoma is closely related to tumor size, depth of invasion and lymphatic metastasis. It can be used as a quantitative indicator of lymphangiogenesis in gastric cancer and contributes to prognosis and evaluation of therapeutic regimen.