HER-2与许多恶性肿瘤的发生、发展密切相关。HER-2可通过信号转导途径间接调控许多肿瘤相关基因的表达,亦可作为转录因子直接调控某些基因的表达,而一些基因表达产物又进而增强HER-2或其他基因的表达,这就构成了以HER-2为中心的基因表达调控网络,这些基因表达产物和HER-2可能共同成为肿瘤诊断和预后的标志物。阐明这个网络中各个分子间的相互作用关系,将为HER-2过表达肿瘤的治疗提供新的药物设计靶标。 HER-2 is closely related to the occurrence and development of many malignant tumors. HER-2 indirectly regulates the expression of many tumor-related genes through signal transduction pathway. It can also directly regulate the expression of some genes as transcription factors, and some gene expression products further enhance the expression of HER-2 or other genes Constitute a HER-2-centered gene expression regulatory network, these gene expression products and HER-2 together may become a tumor diagnosis and prognosis markers. Clarifying the interplay between molecules in this network will provide new drug design targets for the treatment of HER-2 overexpressing tumors.