近十几年来国外发表的大量有关苯妥英钠(DPH)的临床药理和药代动力学研究资料证明:DPH的药效和毒性与其血药浓度密切相关,癫癎患者对药物反应具有明显的个体差异性。因此,对长期服用DPH的患者进行药物血浓度的监测,是非常必要的。最近,我们用高压液相色谱法(HPLC)测定正常人和癫癎病人血浆中苯妥英钠的浓度,取得了满意的 Nearly a dozen years abroad published a large number of clinical pharmacology and pharmacokinetics of phenytoin sodium (DPH) research data show that: the efficacy and toxicity of DPH is closely related to its plasma concentration, epilepsy patients have significant individual differences in drug response Sex. Therefore, the long-term use of DPH in patients with drug blood concentration monitoring is very necessary. Recently, we measured the plasma concentrations of phenytoin in normal and epileptic patients using high-pressure liquid chromatography (HPLC) and achieved satisfactory