施特劳伯(1911)曾发现当小白鼠应用嗎啡后常出现尾强直成“S”型上举的灵敏生物反应,并冠以他自己的名字。随后Herrmann(1912)在証实上述施氏反应的同时还发现常伴有不安靜,反射兴奋,后肢伸瘫以及脊柱前凸等现象。Van Leersum(1918)也发现同时还有排便及会阴部隆凸的现象,于是把这种举尾反应均归結到系由于括約肌的痉挛。因此直到最近的 Strauber (1911) has found that when the mice morphine morphine often appear tail straight into the “S” type of sensitive biological reaction, and under his own name. Then Herrmann (1912) in the confirmation of the above Shi Shi reaction was also found often accompanied by anaerobic, reflex excitement, hind limb extensor and lordosis and other phenomena. Van Leersum (1918) also found that there is also a combination of defecation and perineal protuberances, so the tail lift reaction is attributed to the Department because of the spasm of the sphincter. So until recently